Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
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منابع مشابه
Histamine H3 Receptor: A Novel Therapeutic Target in Alcohol Dependence?
The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in several models, like operant alcohol administration and drinking in the dark paradigm. Alcohol-induced place preference is also affected by these d...
متن کاملHistamine and H3 receptor in alcohol-related behaviors.
Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels are higher in alcohol-preferring than in alcohol-nonpreferring rat brains, and expression of histamine H(3) receptor (H(3)R) is different in key areas for addictive behavior. H(3)R inverse agonists decrease alcohol resp...
متن کاملJPET Miniseries: H3 Receptors Histamine and H3 Receptor in Alcohol-Related Behaviors
Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels are higher in alcohol-preferring than in alcohol-nonpreferring rat brains, and expression of histamine H3 receptor (H3R) is different in key areas for addictive behavior. H3R inverse agonists decrease alcohol responding...
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Brain histaminergic neurons play a prominent role in arousal and maintenance of wakefulness (W). H(3)-receptors control the activity of histaminergic neurons through presynaptic autoinhibition. The role of H(3)-receptor antagonists/inverse agonists (H(3)R-antagonists) in the potential therapy of vigilance deficiency and sleep-wake disorders were studied by assessing their effects on the mouse c...
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The liver X receptors alpha and beta are orphan nuclear receptors that are key regulators in maintaining cholesterol homeostasis. Originally they were found to play an important role in reverse cholesterol transport, a pathway for the removal of excess cellular cholesterol. However several groups have now shown that the liver X receptors also functions in lipid and carbohydrate metabolism, cell...
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2012
ISSN: 1662-5137
DOI: 10.3389/fnsys.2012.00036